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건강기능성식품 실험실

  • 이름 : 장해동
  • 영문 : Jang Hae Dong
  • 직위 : 교수
  • 연구실 : 730105A(연구실) / 730105(실험실)
  • 연락처 :
    e-mail -
    tel - 042) 629-8795 (연구실), 042) 629-8796 (실험실)
    fax - 042) 636-0268


연구분야

식품 중에 존재하는 생리활성물질의 다양한 생리활성 (항산화, 항골다공증, 항비만 및 항암 활성)을 in vitro, cell 및 animal model을 사용하여 분석하고 관여하는 작용기전을 밝혀 건강기능식품개발에 활용하는 연구를 수행한다.
현재 진행 중인 연구는 다음과 같다.

1) 활성산소 (ROS)를 조절함으로써 파골세포 (osteoclast)의 분화를 억제시키는 항골다공증 소재 개발
2) 활성산소 (ROS)를 조절함으로써 지방세포(adipocyte)의 분화를 억제시키는 항비만 소재 개발
3) 시베리아 차가버섯 (Chaga mushroom) 항암 및 항골다공증 활성과 작용기전

연구활동

2015

1) Sang-Hyun Lee, Hae-Dong Jang: Scoparone attenuates RANKL-induced osteoclastic differentiation through controlling reactive oxygen species production and scavenging. Experimental Cell Research 331: 267-277 (2015)

2) Xi-Tao Yan, Sang-Hyun Lee, Wei Li, Hae-Dong Jang, Young-Ho Kim: Terpenes an sterols from the fruits of Prunus mume and their inhibitory effect on osteoclast differentiation by suppressing tartrate-resistant acid phosphatase activity. Archive of Pharmacal Research 38: 186-192 (2015)

3) Abubaker M. A. Morgan, Jang Hoon Kim, Hyum Woo Lee, Sang-Hyun Lee, Chi-Hwan Lim. Hae-Dong Jang, Young-Ho Kim; Phytochemical constituents from the aerial part of Ducrosia ismaelis Asch. Natural Product Sciences 21(1): 1-8 (2015)

4) Nguyen Phoung Thao, Bui thi Thuy Luyen, Sang-Hyun Lee Hae-Dong Jang, Phan Van Kiem, Chau Van Minh, Young-Ho Kim; Antiosteoporotic and antioxidant activities of diterpenoids from the Vietnamese soft corals Sinularia maxima and Lobophytum crassum. Medicinal Chemistry Research 24: 3551-3560 (2015)

2014

1) Xi-Tao Yan, Wei Li, Ya-Nan Sun, Seo-Young Yang, Sang-Hyun Lee, Jian-Bo Chen, Hae-Dong Jang, Young-Ho Kim: Identification and biological evaluation od flavonoids from the fruits of Prunus mume. Biorganic & Medicinal Chemistry Letters. 24: 1397-1402 (2014)

2) Xi-Tao Yan, Sang-Hyun lee, Wei Li, Ya-Nan Sun, Seo-Young Yang, Hae-Dong Jang, and Young-Ho Kim: Evaluation of the antioxidant and anti-osteoporosis activities of chemical constituents of the fruits of Prunus mume. Food Chemistry 156: 408-415 (2014)

3) Bui Huu Tai, Phan Van Kiem, Hae-Dong Jang, Young-Ho Kim: Peroxyl radical scavenging capacity of methanolic extracts of Vietnamese medicinal plants. Journal Pharmacological Science 29: 97-103 (2014)

4) Haiyang Dou, Bing Zhou, Hae-Dong Jang, Seung-Ho Lee. Study of antidiabetic activity of wheat and barley starch using asymmetrical flow field-flow fractionation couples with multiangle light scattering. Journal Chromatography A (2014)

5) Ji-Hye Song, Jin-Kyoung Kim, Hae-Dong Jang: Ferulic acid released by treatment with Aspergillus oryzae contributes to cellular antioxidant capacity of wheat germ extract. Food Science and Biotechnology (2014)

6) Sang-Hyun Lee, Jin-Kyoung Kim, Hae-Dong Jang: Genistein inhibits osteoclastic differentiation of Raw 264.7 cells via regulation of ROS production and scavenging. International Journal of Molecular Science (2014)

7) Eun-Ji Choi, Eun-Hye Ka, Cha-Young Jo, Sung-Hoon Jo, Emmanouil Apostolidis, Mee-Sook Lee, Hae-Dong Jang, Young-In Kwon: Comparison of the antimicrobial and antioxidant activities of selected wheat varieties. Food Science and Biotechnology 23: 791-797 (2014)

8) Abubaker M.A. Morgan, Hyun Woo Lee, Sang-Hyun Lee, Chi-Hwan Lim, Hae-Dong Jang, Young-Ho Kim: Anti-osteoporotic and antioxidant activities of chemical constituents of the aerial parts of Ducrosiaismaelis. Bioorganic & Medicinal Chemistry Letters 24: 3434-3439 (2014)

9) Jin-Kyoung Kim, Hae-Dong Jang: Nef2-mediated HO-1 induction coupled with the ERK signaling pathway contributes to indirect antioxidant capacity of caffeic acid phenethyl ester in HepG2 cells. International Journal of Molecular Science 15: 12149-12165 (2014)

10) Bui Thi Luyen, Bui Huu Tai, Nguyen Phuong Thao, Seo Young Yang, Nguyen Manh Cuong, Young In Kwon, Hae-Dong Jang, Young Ho Kim: A new phenylpropanoid and an alkylglycoside from Piper retrofractum leaves with their antioxidant and α-glucosidase inhibitory activity. Bioorganic & Medicinal Chemistry Letters 24: 4120-4124 (2014)

11) Xi-Tao Yan, Yan Ding, Sang Hyun Lee, Wei Li, Ya-Nan Sun, Seo Young Yang, Hae Dong Jang, Young Ho Kim.; Evaluation of the antioxidant activities of natural components of Artemisia iwayomogi. Natural product Science 20(3): 1-6 (2014)

12) Bui Thi Thuy Luyen, Bui Huu Tai, Nguyen Phuong Thao, Sang Hyun Lee, Hae Dong Jang, Young Mi Lee, Young Ho Kim: Evaluation of the anti-osteoporosis and antioxidant activities of phenloic compounds from Euphorbiaa maculata. Journal of Korean Society of Applied Biological Chemistry 57(5): 575-579 (2014)

2013

1) Gyo-Nam Kim, Yun-Jin Lee, Ji-Hye Song, Hae-Dong Jang: Curcumin ameliorates AAPH-induced oxidative stress in HepG2 cells by activating Nrf2. Food Science and Biotechnology 22: 241-247 (2013)

2) Sang-Hyun Lee, Yan Ding, Xi-Tao Yan, Young-Ho Kim, Hae-Dong Jang: Scopoletin and scopolin isolated from Artemisia iwayomogi suppress differentiation of osteoclastic macrophage RAW 264.7 cells by scavenging reactive oxygen species. Journal of Natural Products 76: 615-620 (2013)

3) Myung-Soo Shon, Ji-Hye Song, Jong-Sik Kim, Hae-Dong Jang: Anti-oxidant activity of oil extracted from Korean ginseng and its moisturizing function. Korean Journal of Aesthetics Cosmetology 11: 489-494 (2013)

4) Bing Zhou, Fang-Fang Wang, Hae-Dong Jang: Enhanced antioxidant and antidiabetic activities of barley and wheat after soaking with tea catechin. Food Science and Biotechnology 22: 1753-1761 (2013)